Whole genome sequencing diagnostic yield for paediatric patients with suspected genetic disorders: systematic review, meta-analysis, and GRADE assessment

Table 1 Meta-regression analysis

	Adjusted Beta	Odds Ratio [95% CI]	p-value
Technique (reference = WES)
UC	-1.763	0.17 [0.11—0.27]	< 0.0001
WGS	0.124	1.13 [0.79—1.62]	0.5001
Monogenic disease, yes	0.399	1.49 [1.07—2.07]	0.0174
NICU/PICU setting, yes	-0.252	0.78 [0.56—1.08]	0.1317
Publication date, after 2017 (reference = before 2017)	0.178	1.19 [0.83—1.73]	0.5452

Abbreviations: CI Confidence interval, WES, Whole exome sequencing, WGS Whole genome sequencing, NICU Neonatal intensive care unit, PICU Paediatric intensive care unit, UC Usual care

ISSN: 2049-3258