Table 2 Meta-analysis of the presence of high-risk HPV DNA in women with equivocal cervical cytology, by terminology group (ASCUS, Borderline Dyskaryosis or ASC-US)
From: Metaprop: a Stata command to perform meta-analysis of binomial data
Study | ES | [95% Conf. interval] | ||
|---|---|---|---|---|
ASCUS | ||||
Manos (1999) | 0.395 | 0.364 | 0.426 | |
Bergeron (2000) | 0.432 | 0.339 | 0.53 | |
Lytwyn (2000) | 0.404 | 0.276 | 0.542 | |
Shlay (2000) | 0.313 | 0.248 | 0.383 | |
Morin (2001) | 0.292 | 0.245 | 0.342 | |
Solomon (2001) | 0.568 | 0.547 | 0.588 | |
Kulasingam (2002) | 0.511 | 0.45 | 0.572 | |
Pretorius (2002) | 0.322 | 0.293 | 0.353 | |
Lonky (2003) | 0.46 | 0.401 | 0.521 | |
Wensveen (2003) | 0.453 | 0.371 | 0.537 | |
Rowe (2004) | 0.44 | 0.38 | 0.501 | |
Andersson (2005) | 0.442 | 0.305 | 0.587 | |
Palma (2005) | 0.699 | 0.62 | 0.769 | |
Giovannelli (2005) | 0.228 | 0.147 | 0.328 | |
Kendall (2005) | 0.341 | 0.33 | 0.352 | |
Nieh (2005) | 0.742 | 0.62 | 0.842 | |
Bergeron (2006) | 0.444 | 0.422 | 0.467 | |
Kiatpongsan (2006) | 0.389 | 0.288 | 0.497 | |
Monsonego (2006) | 0.479 | 0.359 | 0.601 | |
Ronco (2007) | 0.314 | 0.281 | 0.349 | |
Sub-total | ||||
Random pooled ES | 0.431 | 0.382 | 0.480 | |
BORDERLINE DYSKARYOS | ||||
Rebello (2001) | 0.413 | 0.301 | 0.533 | |
Zielinski (2001) | 0.347 | 0.284 | 0.415 | |
Cuzick (2003) | 0.26 | 0.185 | 0.347 | |
Guyot (2003) | 0.522 | 0.306 | 0.732 | |
Moss (2006) | 0.456 | 0.44 | 0.473 | |
Cuschieri (2007) | 0.605 | 0.532 | 0.675 | |
Sub-total | ||||
Random pooled ES | 0.428 | 0.341 | 0.516 | |
ASC-US | ||||
Bruner (2004) | 0.269 | 0.182 | 0.371 | |
Kelly (2006) | 0.725 | 0.583 | 0.841 | |
Ko (2006) | 0.401 | 0.381 | 0.421 | |
Selvaggi (2006) | 0.396 | 0.359 | 0.434 | |
Wright (2006) | 0.341 | 0.315 | 0.368 | |
You (2007) | 0.463 | 0.434 | 0.492 | |
Sub-total | ||||
Random pooled ES | 0.416 | 0.360 | 0.472 | |
Overall | ||||
Random pooled ES | 0.428 | 0.395 | 0.461 | |
Test(s) of heterogeneity: | ||||
Heterogeneity statistic | Degrees of freedom | p-value | I 2∗∗ | |
ASCUS | 614.42 | 19 | 0.000 | 96.9% |
BORDERLINE DYSKARYOS | 53.58 | 5 | 0.000 | 90.7% |
ASC-US | 73.92 | 5 | 0.000 | 93.2% |
Overall | 785.77 | 31 | 0.000 | 96.1% |
Random: Rest for heterogeneity between sub-groups: | ||||
0.16 | 2 | 0.925 | ||
** I 2: the variation in ES attributable to heterogeneity | ||||
Significance of test(s) of ES = 0 | ||||
ASCUS | z = 17.22 | p = 0.000 | ||
BORDERLINE | ||||
DYSKARYOS | z = 9.58 | p = 0.000 | ||
ASC-US | z = 14.57 | p = 0.000 | ||
Overall | z = 25.31 | p = 0.000 | ||